Posthepatic Manipulative Blood Extraction with Blood Transfusion Alleviates Liver Transplant Ischemia/Reperfusion Injury and Its Induced Lung Injury

Liver ischemia-reperfusion (I/R) occurs in a number of clinical syndromes, including liver transplantation (Huguet et al., 1994). Liver I/R is a major obstacle to liver transplantation (Rosen et al., 1998; Banga et al., 2005). It causes liver graft primary nonfunction, up to 10% of early liver transplant failures and higher incidence of acute and chronic rejection (Banga et al., 2005; Henderson et al., 1999; Farmer et al., 2008). Despite many experimental improvements and efforts have been made to attenuate liver I/R injury heretofore, clinical liver I/R was not effectively prevented (Olthoff., 2001; Lehmann et al., 2000; Clarke et al., 2009). And apart from the liver injury, extrahepatic factors like pulmonary injury also play an important role in the outcome of liver transplantation recipients (Sykes et al., 2007; Pereboom et al., 2009; Shimizu et al., 2005; Liu et al., 1996). The incidence rate of acute lung injury is about 40% and greatly threatens the lives of recipients and their quality of life after transplantion (Aduen et al., 2003). So it is meaningful to take strategy to protect the lung against liver transplantation induced injury.